Continued emergence of photonics as a powerful and complementary tool to other diagnostic and treatment methods
Overview
From microscopy through laser treatment, drug discovery, in-vivo imaging, pathogen and disease detection, and genetic sequencing, photonics plays an important role in the diagnosis, monitoring and treatment of health-related issues in the biomedical and healthcare industry. Biophotonics offers distinct advantages over other approaches, including the fact that optics is non-contact, offers extremely good resolution of delivery, and enables simultaneous treatment and imaging.
Nanophotonics is increasingly investigated as a means to realize cost-effective, non-invasive medical procedures. Tuned excitation of surface plasmon resonances enable the localized delivery of optical signals, and focused laser radiation can be used to generate so-called optical tweezers to trap and manipulate single cells. By employing sophisticated optical modeling tools, such nanophotonics effects can be prototyped and optimized without the need to develop expensive prototypes.
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"The combination of automatically farming simulations jobs to multiple computers and being able to easily set up optimization tasks with FDTD Solutions 7.5 changes it from a simulation tool to a design tool. Lumerical's engineers have done an excellent job providing solutions to their customers' toughest problems.
- Dr. Annette Grot, Senior Staff Engineer, Pacific BioSciences
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Featured Publications Showcasing Lumerical's Products
| K. Aslan, M. J. R. Previte, Y. Zhang and C. D. Geddes, "Microwave-accelerated surface plasmon-coupled directional luminescence 2: A platform technology for ultra fast and sensitive target DNA detection in whole blood," Journal of Immunological Methods 331, 103-113 (2008) |
| M. H. Chowdhury, S. K. Gray, J. Pond, C. D. Geddes, K. Aslan, and J. R. Lakowicz, "Computational study of fluorescence scattering by silver nanoparticles," J. Opt. Soc. Am. B 24, 2259-2267 (2007) http://www.opticsinfobase.org/abstract.cfm?URI=josab-24-9-2259 |
| M. H. Chowdhury, J. Pond, S. K. Gray and J. R. Lakowicz, "Systematic Computational Study of the Effect of Silver Nanoparticle Dimers on the Coupled Emission from Nearby Fluorophores", J. Phys. Chem. C., 112(30), 11236-11249 (2008). http://pubs.acs.org/cgi-bin/abstract.cgi/jpccck/2008/112/i30/abs/jp802414k.html |
| Mustafa H. Chowdhury, Krishanu Ray, Stephen K. Gray, James Pond and Joseph R. Lakowicz, "Aluminum Nanoparticles as Substrates for Metal-Enhanced Fluorescence in the Ultraviolet for the Label-Free Detection of Biomolecules," Analytical Chemistry 2009 81 (4), 1397-1403 |
| S. Mandal and D. Erickson, "Nanoscale optofluidic sensor arrays," Opt. Express 16, 1623-1631 (2008) http://www.opticsinfobase.org/abstract.cfm?URI=oe-16-3-1623 |
| M. J. R. Previte and C. D. Geddes, "Microwave-Triggered Chemiluminescence with Planar Geometrical Aluminum Substrates: Theory, Simulation and Experiment," Journal of Fluorescence 3 279-287 (2007) DOI: 10.1007/s10895-007-0170-8 http://www.springerlink.com/content/g2gl8t27q306020w |
| K. Ray, M. H. Chowdhury and J. R. Lakowicz, "Aluminum Nanostructured Films as Substrates for Enhanced Fluorescence in the Ultraviolet-Blue Spectral Region," Analytical Chemistry 2007 79 (17), 6480-648 |
| K. Ray, M. H. Chowdhury and J. R. Lakowicz, "Single-Molecule Spectroscopic Study of Enhanced Intrinsic Phycoerythrin Fluorescence on Silver Nanostructured Surfaces," Anal. Chem. 2008, 80, 6942-6948 |
| S. Tanev, J. Pond, P. Paddon, and V. Tuchin, "Simulation techniques enhance cellular nanobioimaging", SPIE Newsroom, 10.1117/2.1200808.1224, (2008). |
| Stoyan Tanev, Wenbo Sun, James Pond, Valery V. Tuchin, and Vladimir P. Zharov, "Flow cytometry with gold nanoparticles and their clusters as scattering contrast agents: FDTD simulation of light-cell interaction," Journal of Biophotonics 2, 505-520 (2009), DOI: 10.1002/jbio.200910039 |
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