Healthcare, Medicine and Biotechnology

Continued emergence of photonics as a powerful and complementary tool to other diagnostic and treatment methods

Overview

From microscopy through laser treatment, drug discovery, in-vivo imaging, pathogen and disease detection, and genetic sequencing, photonics plays an important role in the diagnosis, monitoring and treatment of health-related issues in the biomedical and healthcare industry.  Biophotonics offers distinct advantages over other approaches, including the fact that optics is non-contact, offers extremely good resolution of delivery, and enables simultaneous treatment and imaging.

Nanophotonics is increasingly investigated as a means to realize cost-effective, non-invasive medical procedures.  Tuned excitation of surface plasmon resonances enable the localized delivery of optical signals, and focused laser radiation can be used to generate so-called optical tweezers to trap and manipulate single cells.  By employing sophisticated optical modeling tools, such nanophotonics effects can be prototyped and optimized without the need to develop expensive prototypes.


Pacific Biosciences Logo

"The combination of automatically farming simulations jobs to multiple computers and being able to easily set up optimization tasks with FDTD Solutions 7.5 changes it from a simulation tool to a design tool. Lumerical's engineers have done an excellent job providing solutions to their customers' toughest problems.
- Dr. Annette Grot, Senior Staff Engineer, Pacific BioSciences

Featured Publications Showcasing Lumerical's Products

K. Aslan, M. J. R. Previte, Y. Zhang and C. D. Geddes, "Microwave-accelerated surface plasmon-coupled directional luminescence 2: A platform technology for ultra fast and sensitive target DNA detection in whole blood," Journal of Immunological Methods 331, 103-113 (2008)
M. H. Chowdhury, S. K. Gray, J. Pond, C. D. Geddes, K. Aslan, and J. R. Lakowicz, "Computational study of fluorescence scattering by silver nanoparticles," J. Opt. Soc. Am. B 24, 2259-2267 (2007) http://www.opticsinfobase.org/abstract.cfm?URI=josab-24-9-2259
M. H. Chowdhury, J. Pond, S. K. Gray and J. R. Lakowicz, "Systematic Computational Study of the Effect of Silver Nanoparticle Dimers on the Coupled Emission from Nearby Fluorophores", J. Phys. Chem. C., 112(30), 11236-11249 (2008). http://pubs.acs.org/cgi-bin/abstract.cgi/jpccck/2008/112/i30/abs/jp802414k.html
Mustafa H. Chowdhury, Krishanu Ray, Stephen K. Gray, James Pond and Joseph R. Lakowicz, "Aluminum Nanoparticles as Substrates for Metal-Enhanced Fluorescence in the Ultraviolet for the Label-Free Detection of Biomolecules," Analytical Chemistry 2009 81 (4), 1397-1403
S. Mandal and D. Erickson, "Nanoscale optofluidic sensor arrays," Opt. Express 16, 1623-1631 (2008) http://www.opticsinfobase.org/abstract.cfm?URI=oe-16-3-1623
M. J. R. Previte and C. D. Geddes, "Microwave-Triggered Chemiluminescence with Planar Geometrical Aluminum Substrates: Theory, Simulation and Experiment," Journal of Fluorescence 3 279-287 (2007) DOI: 10.1007/s10895-007-0170-8 http://www.springerlink.com/content/g2gl8t27q306020w
K. Ray, M. H. Chowdhury and J. R. Lakowicz, "Aluminum Nanostructured Films as Substrates for Enhanced Fluorescence in the Ultraviolet-Blue Spectral Region," Analytical Chemistry 2007 79 (17), 6480-648
K. Ray, M. H. Chowdhury and J. R. Lakowicz, "Single-Molecule Spectroscopic Study of Enhanced Intrinsic Phycoerythrin Fluorescence on Silver Nanostructured Surfaces," Anal. Chem. 2008, 80, 6942-6948
S. Tanev, J. Pond, P. Paddon, and V. Tuchin, "Simulation techniques enhance cellular nanobioimaging", SPIE Newsroom, 10.1117/2.1200808.1224, (2008).
Stoyan Tanev, Wenbo Sun, James Pond, Valery V. Tuchin, and Vladimir P. Zharov, "Flow cytometry with gold nanoparticles and their clusters as scattering contrast agents: FDTD simulation of light-cell interaction," Journal of Biophotonics 2, 505-520 (2009), DOI: 10.1002/jbio.200910039
See the complete list ⇒